The University of the Philippines College of Law was founded amidst the rapidly changing political and social landscape of the Philippines in the early 20th century. As the nation transitioned from colonial rule to greater self-governance, the need for well-trained legal professionals became evident. The establishment of the College was part of the University of the Philippines' mission to enhance its academic offerings and serve the educational needs of the growing population. Opening its doors in Manila, the College started with a modest number of students enrolled in its initial classes. The curriculum was designed to equip them with the necessary skills in various areas of law, including civil, criminal, and administrative law.

As the College grew, its influence extended beyond the classroom. It became a breeding ground for future leaders in law, politics, and society. Over the decades, it produced numerous notable alumni who shaped legal practice and policy in the Philippines. The College's commitment to legal education was instrumental in promoting social justice and public service, aligning with the overarching goals of the university. The establishment also marked a significant shift in the approach to legal education in the country, reflecting a transformation towards a more organized and systematic form of legal training.

Through the years, the UP College of Law maintained its status as a premier institution, adapting its programs to meet the challenges of the changing legal landscape. It became known for its rigorous academic standards and its role in advocating for the rule of law and human rights in the Philippines. Events in its history, such as movements for legal reform and advocacy for social change, further solidified its reputation as a leading law school in the region.