The attack at the DusitD2 hotel complex unfolded in the upscale Westlands neighborhood of Nairobi, in one of the city’s popular areas frequented by business travelers and expatriates. The militants from Al-Shabaab, an extremist group based in Somalia with ties to Al-Qaeda, have executed multiple attacks in Kenya in retaliation for Kenya's military presence in Somalia. This operation began mid-morning when several armed gunmen infiltrated the hotel, which was part of a complex that included office spaces and restaurants. The attackers strategically placed explosives and engaged security forces in a fierce gunfight.

As the siege developed, hostages were taken by the militants, creating a standoff situation that drew the attention of local and international media. The Kenya Defense Forces, alongside police, responded quickly to the crisis, creating a perimeter around the area to contain the situation while attempting to rescue hostages. Despite their efforts, the attack left a significant number of casualties, with diverse global citizens among the victims.

The siege lasted for several hours, culminating with the security forces storming the hotel to eliminate the threat. Al-Shabaab later claimed responsibility for the attack, framing it as retaliation against Kenya's ongoing military operations in Somalia. The incident triggered widespread condemnation and heightened security concerns in Nairobi and across Kenya, particularly given the city's role as a regional hub for business and diplomacy.