Wesley College was established in Melbourne, Australia, as a response to the increasing demand for education and the need for institutions reflecting closely held values of its founders, the Methodist Church. Founded in 1866, the college was initially set up in a modest building on St. Kilda Road and aimed to provide a forward-thinking education grounded in Christian principles. The founders believed that education should encompass not only academic knowledge but also moral and ethical development, which they considered essential for young Australians.

As the college grew, it gained a reputation for its high standards of education and innovation in teaching methods. It encouraged an inclusive approach to education, promoting co-education and focusing on the development of critical thinking and creativity among its students. In a time when many educational institutions operated under rigid and traditional standards, Wesley College stood out due to its dynamic curriculum and progressive outlook on educational practices.

Over the years, the college expanded its facilities and curriculum, establishing itself as a leading educational institution in Victoria. It played a vital role in shaping the educational landscape of Australia, influencing many subsequent educational policies and practices. The college's enduring legacy includes its notable alumni who have gone on to contribute in various fields, including arts, sciences, and public service, reinforcing the importance of comprehensive education in society.