The British Royal Navy's HMS Greyhound was part of a convoy escort role when it intercepted the Italian submarine Neghelli in the Aegean Sea. The operation occurred as part of the broader naval engagements in the Mediterranean region, crucial to maintaining supply lines and hindering enemy movements. The confrontation was marked by a series of depth charge attacks led by HMS Greyhound and its escort vessels. The combined efforts of these ships showcased effective anti-submarine warfare tactics that were vital to safeguarding Allied shipping routes in a strategically contested area. After an intensive series of attacks, the Neghelli was confirmed sunk, and no survivors were reported from the submarine's crew. Additionally, this successful engagement demonstrated the growing sophistication of British naval strategies aimed at countering the Axis submarines threatening their maritime operations. The event not only reflected the tactical advancements of the Royal Navy but also highlighted the ongoing battles that characterized the Mediterranean theater during the early years of the war.