The London Lock Hospital, founded in the late 17th century, initially served as a refuge for the treatment of women suffering from venereal diseases. By 1747, the demand for specialized medical care for these diseases had surged, prompting the establishment of a dedicated clinic for venereal diseases within the hospital. This initiative arose in response to the rampant spread of syphilis and gonorrhea during this period, which was a significant public health issue in London and other urban centers across Europe. The clinic was designed to provide both treatment and a safe space for individuals, particularly women, who were often stigmatized due to their conditions.

The establishment of the clinic was groundbreaking, as it sought to combine medical treatment with education about venereal diseases. In an era where discussions around sexual health were taboo, the London Lock Hospital's initiative aimed to promote understanding and mitigate the associated shame and discrimination faced by patients. This integration of education and care marked a turning point in the approach to sexually transmitted infections, highlighting the necessity of addressing both medical and social dimensions of public health.

As the first of its kind, the clinic set a precedent for future healthcare institutions, paving the way for more comprehensive treatments and specialized clinics dedicated to venereal diseases. It also contributed to a gradual professionalization in the field of sexual health, encouraging more open discussions and research into STIs, thereby influencing public health policies in later years.