Air Midwest Flight 5481 was scheduled to operate a regional flight from Charlotte, North Carolina, to Greenville, South Carolina, on a Beechcraft 1900D. Shortly after takeoff from Charlotte-Douglas Airport, the aircraft encountered a steep climb before crashing into an airport maintenance building, resulting in the tragic loss of all 21 people aboard, including 19 passengers and 2 crew members. The National Transportation Safety Board (NTSB) launched an extensive investigation to determine the causes of the crash. The investigation concluded that improper weight distribution and inadequate pre-flight safety checks contributed to the disaster. The aircraft was overloaded and the center of gravity exceeded safe limits due to passenger and cargo placements. Moreover, the pilots failed to recognize the critical flight situation they were facing. This incident led to increased scrutiny of regional airlines and reinforced the importance of adherence to safety protocols in aviation. The crash stands as a reminder of the potential consequences of neglecting operational guidelines.