The siege of Wexford marked a pivotal moment in the English Civil War's Irish campaign, demonstrating Oliver Cromwell's military strategy of swift and decisive assaults against fortified positions held by the Irish Confederacy. Following the capture of Drogheda earlier in the year, Wexford became another target due to its strategic significance and support for the Confederates. On the evening of October 10, Cromwell's forces initiated their attack, utilizing artillery and infantry in a coordinated effort to breach the town's defenses.

The assault on Wexford quickly turned bloody as followers of Cromwell, fueled by orders to show little mercy against perceived enemies, fought not only Confederate soldiers but also civilians who were trapped in the crossfire. Reports indicate that during the tumult, around 2,000 Confederate troops were killed along with approximately 1,500 civilians, many meeting their end as the city's defenders were overwhelmed. This event further highlighted the increased brutality of warfare during this period.

The fall of Wexford confirmed Cromwell’s dominance in Ireland and served to demoralize remaining Irish resistance forces. It also set a precedent for his military approach, which prioritized quick victories and harsh reprisals, thereby establishing a theme that characterized his campaign in Ireland.