The Prelature of the Holy Cross and the Work of God, commonly known as Opus Dei, was established in 1928 by Spanish priest Josemaría Escrivá in Madrid. The founding of this organization was motivated by Escrivá's vision of integrating the spiritual and secular worlds, encouraging laypeople to live their faith through their everyday occupations. He believed that sanctity could be achieved not only through traditional religious practices but also through the work one performs in the secular realm. This approach resonated with many people who sought a connection between their professional lives and spiritual growth.

Initially, Escrivá’s movement began modestly, with just a few individuals who gathered to share their faith and support one another’s spiritual journeys. Over the years, Opus Dei grew rapidly, establishing various institutions and courses aimed at laypeople. A significant aspect of Opus Dei is its emphasis on personal holiness and the call for every individual to find sanctity in their daily life, regardless of their societal status or occupation. This grassroots approach attracted many followers who appreciated the focus on practical spirituality applicable to modern life.

The organization gained official recognition from the Vatican in 1947 and became a personal prelature in 1982, which allowed it a unique status within the Catholic Church. It has since spread globally, promoting its message of finding God in everyday activities and encouraging members to partake in various apostolic missions. The teachings of Opus Dei advocate the idea that professional life and religious devotion are not mutually exclusive but can coexist harmoniously. This innovative perspective on faith and work has inspired countless individuals to rethink their spiritual lives and has left a lasting impact on contemporary Catholic thought.