The surrender of Antioch was a pivotal moment in the Arab–Byzantine wars, reflecting the expansive ambitions of the Rashidun Caliphate following their rapid conquests in the region. After the Battle of the Iron Bridge, which saw fierce fighting, Antioch’s Byzantine defenders could no longer withstand the pressure of the Islamic forces. The battle was fought with great determination on both sides, but the well-coordinated tactics of the Rashidun army ultimately led to a resounding victory. This engagement is notable not only for its military success but also for the strategic implications of Antioch's fall, as it represented a critical loss for the Byzantine Empire and opened up further advances into Byzantine territories in the Levant.

Following the siege and capture of Antioch, the Rashidun Caliphate secured a foothold in one of the most important urban centers of the region. This victory further demonstrated the effectiveness of the Muslim military strategies, including the utilization of both cavalry and infantry units in concert with each other. The ability to besiege and capture key cities like Antioch significantly bolstered the reputation of Rashidun leaders like Caliph Umar ibn al-Khattab, paving the way for future conquests.

The implications of this surrender echoed throughout the subsequent military engagements between the Islamic and Byzantine forces, affecting both the morale of troops and the geopolitical landscape of the region. The city of Antioch, known for its cultural and economic significance, would now undergo a transformation under Islamic rule, influencing the religious and cultural dynamics of the area for centuries to come.