Andreas Michalakopoulos became the Prime Minister of Greece during a time characterized by intense political turbulence and social upheaval that followed the Greco-Turkish War (1919-1922). This conflict left deep scars on Greek society and contributed to a crisis within the government. Michalakopoulos stepped into leadership in a time of urgent need, being tasked with restoring stability and addressing the pressing issues of a divided nation. His administration was short-lived, highlighting the fragile nature of political alliances in the early 20th century Greece.

One of the key challenges during Michalakopoulos’s brief tenure was the persisting division between royalists and republicans, which significantly impacted governance. His government was unable to address the economic distress faced by the populace, which further undermined its credibility. Moreover, Michalakopoulos faced difficulties in reconciling the diverse political factions, each with its own agenda, making substantial legislative progress nearly impossible.

Despite his attempts at governance, Michalakopoulos’s government resigned after only a few months in power. This resignation was symbolic of the broader political instability in Greece at the time. The inability of the political system to provide lasting solutions for the nation's woes underscored the challenges of democratic governance in that period, ultimately leading to the establishment of authoritarian regimes in the years that followed. His administration, though short, was indicative of the transitional state of Greek politics during the interwar years.