The Space Shuttle Atlantis embarked on STS-112, a pivotal mission aimed at furthering the assembly of the International Space Station (ISS). Launching from the Kennedy Space Center in Florida, Atlantis's crew of seven included commander Jeffrey Ashby and pilot William Oefelein. The primary objective of the mission was to deliver the Harmony module, which would serve as a key intersection point for future modules and supplies, enhancing the ISS's capabilities for scientific research and international collaboration in space exploration. The onboard crew also included mission specialists who were tasked with the intricate assembly operations during their time in orbit.

STS-112's significance lay not only in its technical achievements but also in the ongoing international efforts to maintain and expand the ISS. Harmony's installation represented an important step in increasing the station's functionality, allowing for the later addition of various research and laboratory modules. The mission also showcased the advancements in the space shuttle program, in tandem with international partnerships that defined ISS operations, particularly with contributions from the Canadian Space Agency and the European Space Agency.

As Atlantis traveled to orbit, ground control continually monitored its systems to ensure safety and mission success. After launching, the shuttle successfully approached and docked with the ISS, facilitating the transfer of the Harmony module. astronauts executed a series of spacewalks to install the module and secure it to the station. STS-112 culminated in a successful landing back in Florida after a mission that demonstrated the intricate teamwork and coordination necessary for successful space assembly.