The re-election of William McKinley alongside Theodore Roosevelt as the Vice-President marked a pivotal point in American politics at the turn of the century. McKinley, who had originally assumed the presidency in 1897, campaigned on his accomplishments during his first term, especially the nation's economic recovery and expansion following the Panic of 1893. The election took place in a period characterized by a booming industrial economy, with unprecedented growth in manufacturing and infrastructure. McKinley's campaign was notably marked by the slogan "Four More Years of the Full Dinner Pail," which resonated with voters who prioritized economic stability and growth.

As the Democratic Party struggled under the leadership of William Jennings Bryan, who represented a labor-focused platform, the Republican Party presented a counter-narrative emphasizing capitalism and economic achievement. The election saw significant voter turnout and marked the end of a contentious campaign season. McKinley’s electoral victory, combined with Roosevelt's strong appeal as a progressive reformer, paved the way for a more assertive foreign policy, as both leaders would later engage in international affairs, notably with the Philippines and in the Boxer Rebellion. The Republicans also succeeded in winning increased majorities in Congress, which gave them a stronger mandate to implement their policies.

The overwhelming success of the Republican Party not only demonstrated the American populace's support for McKinley's administration but also established a stable political climate that would persist into the early part of the 20th century. Roosevelt's ascendance as a vice-presidential candidate marked the beginning of his political career on the national stage, ultimately leading to his presidency following McKinley’s assassination in 1901. This election solidified the Republican Party's dominance for the following decade, with implications that would shape modern American political discourse.