A Fokker 50 aircraft, operating under a regional airline, took off from Luxembourg Airport on a scheduled flight. Shortly after departure, the aircraft encountered severe weather, resulting in low visibility. Eyewitnesses reported that the plane appeared to struggle in turbulent conditions before losing altitude and ultimately crashing just outside the airport perimeter. Emergency responders arrived on the scene promptly, but despite their efforts, 20 passengers and crew members were declared dead. Only three people managed to survive the accident, suffering various injuries.

The investigation that followed the crash focused on multiple factors contributing to the tragedy. Initial findings suggested that the weather played a critical role, with thick fog severely limiting visibility. The pilot’s decisions and the airline's safety protocols were also scrutinized, leading to discussions on the adequacy of flight training and emergency procedures under adverse weather conditions. The crash prompted calls for enhanced safety measures across the aviation industry in Europe, particularly for regional flights that often operate in less-than-ideal weather environments.

Public reaction was significant, with outpourings of grief from the families of the victims and the broader community. Memorials and tributes were staged in remembrance of those who lost their lives during the incident. The crash served as a stark reminder of the risks involved in air travel, generating discussions on regulations regarding flight operations during inclement weather. Legislation regarding air safety was subsequently reviewed, aiming to prevent future occurrences of similar accidents.