The expedition led by Antonio de Vea embarked on a journey aiming to explore the largely uncharted territories of western Patagonia, particularly focusing on San Rafael Lake. The region had long piqued the interest of explorers due to its stunning landscapes, glacial waters, and diverse ecosystems. Vea, a seasoned explorer and a prominent figure in Spanish exploration, understood the significance of documenting geographic and resource information from this remote area. The expedition was marked by arduous travel through harsh weather and challenging terrain, which included navigating through intricate waterways and dense forests. They encountered various barriers, including natural obstacles and limited supplies, which tested the resilience of the crew.

During the journey, Vea's team documented the unique flora and fauna of the region, providing valuable insights into the biodiversity of western Patagonia. They also had interactions with local indigenous tribes, which enriched their understanding of the human geography of the area. The expedition helped map significant geographical features and contributed to the broader European knowledge of South America, paving the way for future expeditions and settlements in the region. This exploration highlighted the complexities of the environmental landscape and indigenous cultures, setting a precedent for subsequent interactions and explorations in Patagonia.

The successful entry to San Rafael Lake underscored the importance of exploration in the age of discovery, as nations sought new territories for resources, trade, and strategic advantages. The information gathered would later inform colonial interests and military strategies in the continent. Vea’s expedition is an important chapter in the narrative of exploration in South America, representing both the challenges and the discoveries that defined European engagement with this part of the world.