The Amtrak Cascades train 501 derailed on its inaugural run from Seattle to Portland, marking a significant moment in railway history for the Pacific Northwest. The train, traveling at approximately 80 mph, derailed shortly after leaving Union Station in Seattle, as it approached a curve in DuPont, Washington. Approximately 13 of the train's 14 cars derailed, leading to drastic consequences, including six deaths and numerous injuries among the passengers. The line it was traversing had been recently opened, utilizing modern rail infrastructure aimed at improving regional connectivity and efficiency.

Eyewitness accounts describe a chaotic scene as metal and debris littered the area. A significant portion of the train tumbled onto Interstate 5, affecting highway traffic and prompting an immediate response from emergency services. First responders utilized helicopters and ambulances to transport the injured to local hospitals, while the National Transportation Safety Board (NTSB) launched an investigation into the circumstances leading to the derailment. Eyewitness testimonies indicated a feeling of sudden jolting, and reports concerning the train's speed and condition were scrutinized.

In the aftermath, the Amtrak incident raised serious questions about safety protocols related to the operation of passenger trains, particularly on newly opened routes. The investigation revealed shortcomings in both engineering practices and operational oversight. Additionally, the safety features and signaling systems on the tracks were assessed, alongside a review of the training provided to train operators. Factors such as human error and the engineering design of the track were identified as contributing factors to the disaster, prompting discussions about necessary improvements in the American rail system.