Galeazzo di Santa Sofia, an influential Italian anatomist and professor, performed a landmark post-mortem autopsy at the Heiligen-Geist Spital in Vienna, demonstrating a novel approach to medical education in the early 15th century. Prior to this, autopsies were primarily conducted for legal purposes or to ascertain causes of death, rather than for instructive aims. The act of dissecting the human body purely for teaching not only showcased di Santa Sofia's commitment to advancing medical knowledge but also illustrated a broader cultural shift towards empirical investigation in the sciences. This autopsy was conducted meticulously, with the professor likely using various instruments that were beginning to be developed for anatomical studies.The significance of this event lies in its impact on medical education and practice. By performing autopsies to elucidate human anatomy and physiology, di Santa Sofia laid the groundwork for future anatomists and medical professionals to approach their studies with a more rigorous, observational methodology. This practice challenged contemporary beliefs and practices about the human body, pushing the boundaries of accepted medical knowledge. As word of di Santa Sofia's methods spread through Europe, they inspired a new generation of physicians who began to embrace empirical study in their own practices, culminating in the Renaissance's flourishing of anatomical science.The 1400s marked a pivotal point in the history of medicine, where formal medical education began to include dissection as a cornerstone of learning. The acceptance of post-mortem examinations for educational purposes promoted a more scientific approach towards understanding human anatomy and health, eventually leading to significant advancements in medical practice and public health over the following centuries. The impact of Galeazzo di Santa Sofia's actions extended far beyond Vienna, influencing medical instruction throughout Europe and contributing to the professionalization of medicine.