Sepé Tiaraju emerged as a prominent leader of the Guaraní indigenous resistance against the encroachment of Spanish and Portuguese forces in the mid-18th century. The Guaraní had been subjects of the Jesuit Missions, which aimed to protect them from slavery and exploitation by colonial powers. However, as colonial ambitions expanded, tensions mounted, leading to a series of conflicts known as the Guaraní War.

On July 2, 1756, a significant skirmish unfolded in which Sepé Tiaraju was killed. His leadership inspired the Guaraní in their fight for independence and preservation of their culture. The battle was not only a clash of arms but also highlighted the broader struggle of indigenous peoples against colonial forces. The confrontation occurred within the Jesuit Missions territory, an area that had served as both sanctuary and battleground, marked by the complex interplay between colonial interests and indigenous rights.

As the Guaraní forces faced overwhelming odds against the technologically superior Spanish and Portuguese armies, Tiaraju's death dealt a heavy blow to their morale. Despite his sacrifice, the Guaraní's resistance continued for a time, yet without his influential leadership, the fragmentation of their movement began. This skirmish represented a pivotal moment, illustrating the fierce determination of the Guaraní as they fought for their homeland and autonomy, ultimately influencing subsequent engagements in the region.