Arnošt of Pardubice was appointed the Bishop of Prague, marking the end of the traditional cycle of bishops for the diocese. This transformation was significant as it came amidst efforts by the Catholic Church to consolidate its influence and restructure its hierarchy across Europe. In 1343, the church aimed to adapt to changing political and spiritual landscapes. Arnošt, who had been a prominent figure in the development of the church in Bohemia, was entrusted with this important role. His appointment allowed for a stronger connection with the papacy, which was crucial for enforcing ecclesiastical authority and discipline within the rapidly changing religious environment.

This transition was not merely a title change but also signified a pivotal shift in ecclesiastical governance. Within a year, Arnošt of Pardubice became the first Archbishop of Prague, a title that conferred greater power and responsibility. The elevation to archbishopric symbolized a dramatic enhancement of the church's role in governance and social matters within the Kingdom of Bohemia. This new religious governance framework had implications for local politics, law, and social order, as the archbishopric sought to enhance the church's role in shaping public policy and societal norms.

Arnošt's leadership allowed him to forge strong ties with the Crown and exercise influence beyond strictly ecclesiastical matters. He became an architect of various reforms and initiatives within the church that would lay foundations for future religious life in Bohemia. His tenure as bishop, followed by the archbishopric, not only marked a personal achievement but also indicated a substantial shift in the relationship between the church, state, and society, reflecting wider trends in medieval Europe.