Frank Nitti, who served as the boss of the Chicago Outfit after the infamous Al Capone, faced immense challenges in maintaining control of his criminal empire. By the early 1940s, federal authorities intensified their fight against organized crime, and Nitti found himself increasingly under pressure. On March 19, 1943, Nitti chose to end his life, succumbing to the pressure that came from both law enforcement and the shifting dynamics within the organized crime community that had largely rejected traditional mob practices.

The chosen location for his suicide, the Chicago Central Railyard, was significant as it was a bustling hub of activity and represented the organized crime's connections to various illicit activities, including racketeering and bootlegging. Nitti's death was shocking and sent ripples through the criminal underworld, as he was known for his cunning tactics and deep ties within the Mafia. His reign over the Outfit was marked by both profit and struggle, and his inability to adapt to the changing environment ultimately led to his demise.

In the aftermath, Nitti's suicide symbolized the decline of the highly organized crime syndicate that once thrived under Capone's leadership. The challenges faced by organized crime in the post-Capone era included increased law enforcement scrutiny and public backlash against mob activities, which would lead to a transformation within the criminal enterprises in America. The Chicago Outfit would continue to exist, but it faced a fractured leadership structure and was forced to contend with emerging rival factions. Nitti's legacy would linger, and his life and death became cautionary tales of the violent world of organized crime.