During the First Balkan War, the Greek army sought to reclaim territories in the region of Epirus, which had significant historical and cultural ties to Greece. The battle at Bizani, a strategic location near the town of Ioannina, was a key component of this endeavor. The Greek forces, well-prepared and animated by the aspirations of national unification, engaged the Ottoman army on April 3. They successfully launched an organized offensive that caught the Turkish troops somewhat off-guard, leveraging their knowledge of the local terrain.

The fighting was intense, characterized by both conventional military tactics and guerrilla warfare, reflecting the challenging conditions of the battlefield. Despite facing difficulties such as supply shortages and harsh weather conditions, Greek commanders, including General Konstantinos Manos, displayed remarkable leadership. By April 5, Greek forces had not only managed to secure a decisive victory at Bizani but also succeeded in capturing the strategically important city of Ioannina shortly thereafter.

This victory was pivotal in demonstrating the determination of the Greek military and its ability to coordinate effectively against a historically established opponent. It also set the stage for further Greek territorial claims in the region, emphasizing the aspirations of the newly formed Balkan League, comprised of Serbia, Bulgaria, Greece, and Montenegro, all seeking to diminish Ottoman influence in the Balkans. The success at Bizani highlighted the tide turning against the Ottomans, foreshadowing their decline in the region and serving as a precursor to the eventual reshaping of Balkan national borders.