Deshin Shekpa, widely known as the 5th Karmapa Lama, played a crucial role in the history of Tibetan Buddhism and its relations with other cultures. His journey to Nanjing was marked by a significant recognition: he was conferred the title 'Great Treasure Prince of Dharma' by the Ming dynasty's Yongle Emperor. This accolade not only showcased the Ming dynasty's recognition of Tibetan Buddhism but also emphasized the diplomatic interactions between Tibet and China during the early 15th century. The visit highlighted the mutual respect and influence that the two cultures shared, paving the way for further cultural exchanges.

During his time in Nanjing, Karmapa Lama's presence attracted various dignitaries and followers, further illuminating the spiritual significance of the visit. The Ming dynasty, known for its cultural achievements and strong governance, sought to consolidate its power and influence, and by inviting religious leaders like the Karmapa, they sought to validate their rule through religious endorsement. The meeting between the Karmapa and the emperor symbolizes the intersection of politics and spirituality, which was a hallmark of the era.

Additionally, the title 'Great Treasure Prince of Dharma' reflects the Karmapa's esteemed position within Tibetan Buddhism and his role as a spiritual leader capable of bridging diverse cultural landscapes. This not only enhanced his standing among Tibetan Buddhists but also increased the prestige of the Ming dynasty in the eyes of their own subjects and surrounding regions. The visit would resonate for generations to come, influencing not only religious practices but also forming a foundation for future interactions between Tibet and China.