The disaster began with the SS Grandcamp, a freighter loading ammonium nitrate fertilizer at the Texas City port. On April 16, an accidental fire ignited on the ship, triggering a catastrophic explosion that was felt miles away. The initial blast propelled debris and shrapnel through the air, obliterating the dock and shattering windows in buildings several blocks distant. In the immediate aftermath, a chain reaction occurred as nearby vessels caught fire, including another freighter, the SS High Flyer, which also exploded a short time later.

The explosion generated a shockwave that leveled parts of Texas City, leading to widespread destruction of homes, businesses, and industrial facilities. Emergency responders were overwhelmed as they rushed to the scene to rescue trapped individuals. Many first responders and civilians who tried to help were also victims of subsequent explosions. The chaos lasted for hours, with intense fires burning for days afterwards.

In total, nearly 600 people were killed, with thousands more injured. The recovery process was extensive, and the community had to cope with a significant loss of life and property. Cleanup and rebuilding efforts began almost immediately, alongside investigations into safety protocols regarding the handling of hazardous materials.