American Flyers Airlines Flight 280/D was operating a scheduled passenger service from Miami, Florida, to Ardmore, Oklahoma when it experienced a catastrophic failure on approach to Ardmore Municipal Airport. The aircraft, a Lockheed L-188 Electra, was carrying a total of 83 passengers and crew when it went down in a field approximately 2 miles from the runway. This tragic event unfolded in the morning hours, with the aircraft losing altitude rapidly before impacting the ground. Eyewitnesses reported seeing the plane struggling before crashing, resulting in a fiery impact that left no survivors.

Investigations into the crash revealed potential issues with the aircraft's engines, raising alarms about the maintenance practices of American Flyers Airlines. The National Transportation Safety Board (NTSB) launched a thorough investigation into the incident, focusing on technical failures and operational shortcomings. The findings revealed multiple contributing factors, including possible pilot error and mechanical failure. This tragedy became one of the deadliest air disasters in the United States during the 1960s, emphasizing the need for stricter safety regulations and oversight in the aviation industry.

In the aftermath, the U.S. Federal Aviation Administration (FAA) reviewed existing safety regulations and maintenance protocols for airlines, leading to enhancements in training and inspections. The crash significantly impacted public perception of air travel safety during a time of rapid growth for the aviation industry. Memorials were held for the victims, and this incident became a poignant reminder of the inherent risks associated with air travel and the importance of stringent regulations to prevent future tragedies.