Auguste Deter was a German woman who, in the early 20th century, became the first known individual diagnosed with Alzheimer's disease. Her condition was noted by Dr. Alois Alzheimer, a German psychiatrist and neurologist, who gave her a diagnosis in 1901, after she exhibited significant memory loss and changes in behavior. Deter exhibited symptoms such as disorientation and difficulty in performing everyday activities, a pattern observed in many later diagnosed cases of dementia. Alzheimer's interest in her case led to a rich clinical assessment that would inform future studies on cognitive decline. Deter ultimately died in 1906, marking a significant moment in the recognition of dementia.Dr. Alzheimer’s documentation of Deter's case included extensive notes on her psychological symptoms and changes in brain function. Her post-mortem examination revealed neurofibrillary tangles and senile plaques, which are now recognized as the hallmark features of Alzheimer's disease. This discovery was crucial in linking the clinical symptoms of dementia to specific pathophysiological changes in the brain, and it paved the way for further research in neurodegenerative diseases. The case was presented at a medical conference, capturing the attention of the medical community and initiating further investigation into similar conditions.The legacy left by Auguste Deter is profound, representing a pivotal moment in the understanding of Alzheimer's disease and dementia. Subsequent studies in the field have sought to explore treatment options, the disease's underlying mechanisms, and ultimately how to improve the lives of those affected by cognitive decline. Deter’s diagnosis was not just a medical milestone; it gave way to an entire field of study that aims to understand and combat the complexities surrounding Alzheimer's disease.