Santiago de Vera's appointment as the governor-general of the Spanish colony in the Philippines marked a pivotal moment in the colonial administration of the archipelago. Vera succeeded several predecessors who had faced considerable difficulties in managing the colony, including local resistance and logistical challenges. His background in administration and governance was recognized as crucial for addressing these issues. Vera's primary objectives included stabilizing the volatile political situation, enhancing trade, and ensuring the welfare of the colonial community. He took immediate steps to fortify defenses against potential incursions from rival colonial powers and reiterated the importance of trade routes that were vital for the Spanish economy.

Under Vera's leadership, efforts were made to improve relations with local leaders, which was essential in reducing tensions and fostering cooperation. This approach led to various agreements that helped secure a more stable environment for both the Spanish settlers and the indigenous populace. Additionally, Vera implemented reforms aimed at streamlining governance, which were necessary due to the previously high turnover of leadership that disrupted continuity in policy and strategy. His ability to address pressing concerns would influence subsequent administrations in the Philippines and set a precedent for governance.

Vera's tenure was characterized not only by internal improvements but also by the broader geopolitical context of European colonial ambitions in the region. His administration had to navigate complex relations with competing powers while also managing the aspirations of local populations. As he sought to maintain Spanish supremacy in the islands, his efforts contributed to the development of administrative structures that would later play a significant role in the colonial governance of the Philippines. Santiago de Vera's appointment reflects the ongoing evolution of the Spanish colonial enterprise in the archipelago and provides insights into the administrative challenges faced by early colonial leaders.