The siege of Antioch was part of the ongoing conflict between Crusader states and Muslim powers in the Eastern Mediterranean. The city of Antioch, founded in ancient times and later a vital Crusader stronghold, was besieged by the Mamluks led by Sultan Baibars. Following the successful campaign against the Crusader stronghold of Tripoli, Baibars aimed to consolidate Mamluk power by targeting Antioch, which had been weakened over the years due to internal strife and external threats. Baibars’ forces effectively encircled the city, cutting off supply lines and launching persistent assaults.

The siege's conclusion came after a sustained effort that involved both direct military action and psychological warfare against the defenders. On May 18, more than 800 years after its founding, Antioch fell to Baibars, changing the balance of power in the region. The defenders, cannot muster enough resources to withstand the final onslaught, surrendered, leading to pillaging and the eventual integration of the city into the Mamluk Sultanate.

The fall of Antioch marked a definitive shift in control, as it eliminated one of the last major Crusader enclaves in the Near East. The Mamluks began to assert dominance over former Crusader territories, further challenging any remaining Christian military presence in the region. The successful siege not only shifted territorial control but also inspired the Mamluks, setting the stage for future battles against remaining Crusader states and eventually leading to greater Muslim unity under Mamluk leadership against outside threats.