The earthquake that struck Istanbul and the Marmara region was one of the critical seismic events of the 18th century, profoundly impacting the socio-economic landscape of the area. Recorded at an estimated magnitude of 7.4, this earthquake led to widespread devastation, with significant structural damage observed in numerous buildings, including homes, churches, and administrative offices. The geological conditions of the region contribute to its vulnerability to earthquakes, as it sits near active fault lines.

In Istanbul specifically, many historical structures faced irreparable damage. The quake's effects were felt across a vast area, impacting neighboring settlements and resulting in a significant number of deaths. The local population, largely unprepared for such a catastrophic event, struggled to cope with the aftermath, as rescue efforts were hampered by aftershocks and the disaster's scale. This earthquake not only resulted in immediate loss of life and infrastructure but also led to a long-term reconstruction effort that would shape the urban landscape for decades.

This seismic event served as a warning and was significant in terms of Turkish disasters of the time, pushing governing authorities towards improving construction standards and urban planning in seismic-prone urban areas. The resilience and adaptability of the community in facing such disasters have become intrinsic to Istanbul's history, reflecting the ability of cities to rebuild and fortify in the wake of natural calamities.