The Battle of Landriano, fought during the War of the League of Cognac, occurred between the French and Spanish forces in June 1529. The conflict was primarily driven by the geopolitical desires of various European powers vying for control over northern Italy, a region of significant strategic importance. The Spanish forces, commanded by Antonio de Leyva, faced off against the French under the leadership of François de Lorraine. This clash followed a series of earlier confrontations in Italy, reflecting the ongoing struggle for dominance within the Italian Peninsula. The French had previously achieved significant victories, but their position began to deteriorate during this period.

On the day of the battle, the Spanish troops utilized their well-organized infantry formations to launch an effective counter-offensive against the French. The outcome was heavily influenced by both tactical maneuvering and the morale of the troops. The defeat at Landriano led to a retreat for the French forces, marking a turning point in their campaign in Italy. Following this battle, the Spanish solidified their control over northern Italy, leading to a shift in alliances and power dynamics throughout Europe.

The aftermath of the battle saw increased tensions between France and Spain and contributed to ongoing conflicts over territorial claims in Italy. The Spanish victory at Landriano not only altered the course of the War of the League of Cognac but also set the stage for future engagements between these European powers. As a result, Spain emerged as a dominant force in Italy, influencing political and military strategies in the region well into the future.