The Great Siege of Malta, occurring from May to September, was a critical confrontation between the Ottoman Empire and the Knights Hospitaller, representing a fierce struggle for control over the strategically significant island of Malta. Dragut, also known as Turgut Reis, was an influential Ottoman admiral and one of the key figures commanding the naval operations during this campaign. Known for his brilliant tactics and experience in naval warfare, Dragut's capabilities were pivotal in maintaining blockades and launching assaults against the besieged positions held by the Knights. As the battle intensified, Dragut fell wounded due to a sniper's shot while commanding his forces. His death on June 23 had immediate repercussions, as the Ottomans began to lose their momentum. The command was thrown into disarray following his loss, as they struggled to fill the leadership void he left behind.

After Dragut's death, his fleet's morale and coherence were severely impacted. Stories of his death spread quickly, often demoralizing the Ottoman troops, who had previously viewed Dragut as an invincible leader. The Knights of St. John seized the opportunity to bolster their defenses, drawing on their dwindling supplies and reinforcements, and mounting more coordinated resistance against the besieger. As months passed, the siege would culminate in a decisive defeat for the Ottoman forces, largely attributed to the lack of effective command after Dragut's death. The Knights, under Grand Master Jean Parisot de la Valette, rallied their forces and demonstrated exemplary defense against the prolonged siege, leading to a pivotal moment in European history.