Famagusta, a key Venetian stronghold on the island of Cyprus, found itself besieged by Ottoman forces under the command of Grand Vizier Mustafa Pasha. The siege began in the spring, and despite valiant efforts from the Venetian defenders led by Marco Antonio Bragadin, the city's defenses were eventually breached. The prolonged conflict captured the interest of Europe, reflecting the broader struggle for control over the eastern Mediterranean region. Famagusta was fortified and known for its impressive walls, but the siege demonstrated the increasing military prowess of the Ottomans.

Negotiations culminated in August when Bragadin agreed to surrender in exchange for safe passage for his men and the civilians of the city. The Ottomans honored this agreement, leading to the peaceful evacuation of Venetian defenders and residents. However, the aftermath of the surrender saw Bragadin betrayed and executed, which sparked outrage and served as a grim reminder of the ruthlessness of the Ottoman advance. This event not only marked the end of Venetian dominance in Cyprus but also showcased the Ottomans' expanding influence in the Mediterranean.

Following the surrender, Cyprus remained under Ottoman rule for over three centuries, profoundly altering the island's demographic, cultural, and religious landscape. Famagusta, once a vibrant center of Venetian trade and culture, became a provincial city in the Ottoman Empire, impacting local economies and social structures. The fall of Famagusta was instrumental in shaping the political map of the region in the years to come, as European powers recalibrated their strategies in response to the Ottoman expansion.