The first engagement of the Battle of Zonchio took place when the Venetian and Ottoman fleets clashed off the coast of Zonchio, near the island of Zante (modern-day Zakynthos, Greece). This initial confrontation was indicative of the growing tensions between the Republic of Venice and the Ottoman Empire, which were vying for supremacy over trade routes and territorial control in the Eastern Mediterranean. Venice, known for its powerful navy and merchant fleet, sought to protect its trading interests against Ottoman expansion. Conversely, the Ottomans aimed to secure their maritime routes and project power in the region.

On August 12, Admiral Francesco Grimani led the Venetian fleet in what was a critical maneuver against Kemal Reis, the Ottoman commander, who brought a larger number of ships to the conflict. The battle was significant not only for its immediate tactical encounters but also for the advanced naval techniques employed, including the use of artillery on ships, which was relatively new at the time. The engagement saw heavy exchanges of cannon fire, showcasing the evolving technology and strategies in naval warfare.

Despite the efforts of the Venetians, the battle ended in a retreat for their fleet, although it set the stage for further confrontations between both powers. This engagement marked the beginning of a series of naval battles that would continue throughout the late 15th and early 16th centuries as the two empires fought for control over trade routes and territories in the Mediterranean.