With the passing of Pope Hormisdas, the papal seat was occupied by John I, who would lead the Catholic Church through a pivotal period. Information about John I's early life is sparse, but he was likely born in Italy and was a priest prior to his election as pope. Hormisdas' papacy had been marked by significant ecclesiastical challenges, including the Acacian Schism, which had divided Eastern and Western Christianity. John I was elected amid this backdrop of division, as the church sought a leader capable of reconciling differing factions within Christianity.

His tenure as pope was not only a continuation of Hormisdas' policies but also a period where John I sought to strengthen the position of the papacy amidst external pressures. He was known for his moderate approach, often favoring diplomacy over confrontation with various theological groups. Notably, John I's papacy would see him engaging with both the Goths and the Byzantine Empire, as he worked towards stabilizing relationships that were crucial for the growth of the Christian faith.

One of the most significant aspects of John I's papacy was his liaison with the Arian king Theodoric the Great, who ruled over Italy and was known for his Arian beliefs. John I's ability to navigate these complex religious dynamics demonstrated his commitment to maintaining the integrity of the Catholic doctrine while ensuring the safety and prosperity of his followers. Under his leadership, he focused on reinforcing church authority and addressing issues of theological contention, marking an important chapter in early Christian history.