The expulsion of Jews from Spain in 1492 was a pivotal moment marked by the Alhambra Decree issued by King Ferdinand II of Aragon and Queen Isabella I of Castile. This decree led to the forced removal or conversion of as many as 200,000 Jews, prompting widespread distress. In the wake of this crisis, Sultan Bayezid II of the Ottoman Empire demonstrated a humanitarian approach by mobilizing the Ottoman Navy to assist those fleeing persecution. The fleet was tasked with ensuring safe passage to Ottoman territories, particularly focusing on cities such as Thessaloniki and İzmir, which were historically known for their vibrant Jewish communities.Bayezid II's intervention was significant in multiple dimensions. First, it illustrated the Ottoman Empire's policy of religious tolerance, contrasting sharply with the actions taken by the Spanish monarchy. It also allowed the Ottoman Empire to bolster its economic and cultural fabric by integrating a diverse group of skilled individuals and families who had been expelled. The influx of Jewish migrants enriched Ottoman society and helped to establish thriving communities in the newly acquired lands. Overall, this response not only provided refuge but also laid the groundwork for a more pluralistic society in the empire, which would be beneficial for centuries to come.