Silliman University was founded in Dumaguete, Philippines, in 1901, and marked a significant milestone as the first American private educational institution in the country. The initiative was led by Dr. David Silliman, who was inspired by the need for an American-style education amidst the backdrop of the Philippines' transition to American rule following the Spanish-American War. With support from the American Missionary Association, the university aimed to provide a comprehensive and modern education to the Filipino people, blending local customs with American educational practices. The first classes were conducted in a modest building, which set the stage for future developments.

The university initially focused on a curriculum that included liberal arts, sciences, and theology, reflecting the American educational philosophy of the time. As the years progressed, Silliman University expanded its facilities and academic offerings, becoming a vital educational center in the region. The establishment served not just as a place for academic pursuit, but also as a cultural hub, where American and Filipino traditions began to intermingle. The institution grew in stature, contributing significantly to the intellectual and social landscape of the Philippines.

Over the decades, Silliman University has achieved recognition and growth, becoming a key player in the development of higher education in the Philippines. It has experienced various transformations in response to the changing educational and social needs of the country. Silliman University holds a unique place in Philippine history as a pioneering institution that championed the ideals of American education while respecting and incorporating Filipino culture into its programs. The lasting legacy of Silliman University has continued to influence educational practices in the Philippines, shaping generations of leaders and thinkers.