In 1634, a catastrophic explosion rocked Valletta, Malta, originating from a local gunpowder factory. The facility, essential for producing munitions for the Knights of St. John, experienced a massive blast that killed 22 workers and civilians on-site. Testimonies suggested that the explosion occurred due to inadequate safety measures, particularly concerning the storage and handling of volatile materials. Witnesses reported a loud bang followed by fires that erupted in the immediate area, leading to chaotic scenes as residents fled or attempted to save those trapped.

The aftermath of the explosion saw significant damage inflicted upon several surrounding buildings, leading to a rapid response from the local authorities. Emergency services and the Knights of St. John were quick to assess the situation, providing aid to the injured and beginning the recovery process for the affected structures. Investigations were launched to determine the root causes of the explosion, prompting discussions about the need for stricter safety regulations and the handling of explosive materials within the city.

This incident highlighted the risks associated with industrial activities, especially in densely populated urban centers like Valletta. The explosion not only strained local resources but also raised awareness of the need for systemic safety changes. As Valletta was a strategic location for military operations, ensuring the safety of supply production became paramount for its leadership and military strategists moving forward.