Fort Manoel was commissioned by Grand Master António Manoel de Vilhena as part of a broader strategy to fortify Malta against potential naval threats, particularly from the Ottomans. The construction began with the laying of the first stone on September 14, 1723, marking the start of a significant military project. The fort was strategically placed on Manoel Island, situated between Valletta and Sliema, allowing for a commanding view of the surrounding waters. The fort was designed by the Italian architect Giovanni Sante Bianchi, who was known for his expertise in military architecture.

Over the years, Fort Manoel became an essential bastion for the Knights of St. John, serving as both a military stronghold and a symbol of their resilience in the face of external threats. The design featured a pentagonal shape, thick walls, and a central barrack structure, providing a robust defense mechanism. Construction work progressed quickly, with the fort being completed in 1733, featuring a series of bastions equipped with artillery to protect against possible sea incursions.

As Malta’s geopolitical significance grew, Fort Manoel played a critical role in various military campaigns, particularly during the 18th century. Its design not only contributed to Malta's defense but also reflected the architectural innovations of the time, blending functionality with aesthetics. Over the centuries, despite experiencing periods of neglect, the fort has been preserved and remains an important landmark reflecting Malta’s rich military history.