The Great Prussian Uprising began in 1260 when the indigenous Prussian tribes rose in revolt against the oppressive rule of the Teutonic Knights. These Knights had been involved in the Christianization of the Prussian territories since the early 13th century, often employing violent methods to convert the native population. By this time, the native tribes had grown increasingly resentful of their loss of autonomy, growing oppression, and their lands being taken over by the expanding power of the Teutonic Knights.

The uprising was not a singular event but a concerted effort by multiple tribes, most notably the Warmians and Natangians, who were determined to resist the foreign invaders and reclaim their independence. The revolt was marked by significant battles, strategic guerrilla tactics, and a wide array of local support, indicating a deep-seated desire for liberation among the Prussians. The conflict further intensified with the Knights dispatching additional reinforcements, leading to prolonged confrontations that lasted several years.

As the uprising gained momentum, it drew in various other local factions, uniting disparate groups under a common cause. Not only did this conflict have immediate consequences for the Prussian tribes and the Knights, but it also had long-term implications for the region, illustrating the complex dynamics between colonization, cultural identity, and resistance. The uprising represents a pivotal moment in the history of Prussia, showcasing the fierce resistance of indigenous cultures against external powers and their attempts to impose religion and control over local populations.