The Battle of Boquerón initiated a crucial phase in the Chaco War, a conflict driven by both Paraguay and Bolivia's desires to control the Chaco Boreal region, believed to be rich in oil reserves and other natural resources. On September 7, 1932, Paraguayan troops launched an offensive against Bolivian positions in Boquerón, known for its strategic importance in the area. The battle quickly escalated, with both sides engaging in intense combat. The Paraguayan forces employed new military strategies and tactics, reflecting lessons learned from World War I, which led to fierce fighting that resulted in heavy casualties.

Over the course of the battle, the Paraguayan army faced several logistical challenges, including extreme weather conditions, supply shortages, and the harsh terrain of the Chaco region. Nevertheless, their determination and improved military organization contributed significantly to their early successes in the battle. The Bolivian forces, seasoned in defense, were caught in an unexpected situation, leading to a protracted struggle characterized by trench warfare and the use of machine guns.

The Battle of Boquerón would ultimately mark a turning point in the Chaco War, demonstrating the effectiveness of Paraguay's offensive military strategy and setting the stage for further confrontations. This battle highlighted the geopolitical tensions in South America during the early 20th century.